Skip to main content
. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Curr Allergy Asthma Rep. 2014 Jan;14(1):404. doi: 10.1007/s11882-013-0404-6

Table 1.

Studies testing dietary interventions in models of autoimmune diseases

Dietary factor Disease model Ref. Overall effect Putative mechanisms
Calorie restriction EAE [56] Beneficial Curtailment of leptin
Calorie restriction EAE [95] Beneficial Curtailment of leptin
PUFA EAE [96] Beneficial PPAR-γ induction
Olive oil and polyphenols DIC [97] Beneficial PPAR-γ induction
Fish-oil CIA [98] Beneficial Macrophage function
Green tea extract EAE [99] Beneficial NFκB inhibition
High-fat diet IBD [50] Detrimental Unknown
High-fat diet CIA [51] Detrimental TH17 induction
High-fat diet EAE, TNBS Colitis [44] Detrimental TH17 induction
High-salt diet EAE [74] Detrimental TH17 induction
High-salt diet EAE [73] Detrimental TH17 induction
Trans fatty acids DIC [100] Detrimental TH17 induction

EAE Experimental autoimmune encephalomyelitis, CIA collagen-induced arthritis, DIC DSS-induced colitis, PUFA polyunsaturated fatty acid, TNBS trinitrobenzenesulfonic acid