Figure 3. Estrogen protected against the development of aneurysmal rupture in ovariectomized female mice.
A: Incidence of ruptured and unruptured aneurysms. B: Rupture rate. C: Survival curve. Survival curves were constructed after excluding those mice that did not have aneurysms so that the curves mimic clinical settings. * vs vehicle, # vs Estrogen + ER antagonist. ER: estrogen receptor.