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. Author manuscript; available in PMC: 2014 May 27.
Published in final edited form as: Cell Rep. 2014 Apr 13;7(2):412–423. doi: 10.1016/j.celrep.2014.03.025

Figure 2. Loss of FLCN increases pulmonary alveoli, impairs lung function and induces alveolar epithelial cell apoptosis.

Figure 2

(A–C) Flcn loss results in alveolar enlargement in Flcnf/f:SP-C-Cre mice treated as in (1D). Scale bars, 200 μM.

(D–F) Enlarged alveoli in pups with FLCN deletion in lung epithelium. Scale bars, 200 μM.

(G) FLCN deletion in Flcnf/f:SP-C-Cre mice impairs lung function, n=8 per group. BL–baseline; S-saline.

The mean is shown; error bars represent SE (n>3). Data for Dox- mice are taken as one fold.

(H) Cleaved caspase-3-positive (red) cells in lung epithelium (SP-C, green) of BHD lung, (n=5) but not in control (n=3) lung.

(I) Loss of Flcn in lung epithelium (SP-C, green) results in alveolar epithelial cell apoptosis (red) in lung from Flcnf/f:SP-C-Cre mice treated as in (1D), n=3 per group.

Scale bars, 20 μM.

See also Figure S2.