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. Author manuscript; available in PMC: 2014 May 27.
Published in final edited form as: Cell Rep. 2014 Apr 13;7(2):412–423. doi: 10.1016/j.celrep.2014.03.025

Figure 4. FLCN regulates LKB1 levels and AMPK phosphorylation.

Figure 4

(A) Primary lung AECs from FLCNf/f mice were infected with control (−) or Cre- recombinase-expressing adenovirus (AdCre,+) followed by immunoblot analysis. See also Figure S3.

(B) Immunoblot analyses of mouse epithelial NMuMG cells transfected with Flcn siRNA (siFlcn) or control scrambled siRNA (−).

(C) Re-expression of FLCN in human FLCN-null UOK-257 cells increases membrane localization of LKB1.

Top: representative images. Bottom: statistical analyses. Protein ratio for control cells were taken as one fold. Data are mean ± SE, n=3.