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. 2013 Dec 30;66(1):78–89. doi: 10.1002/art.38199

Figure 4.

Figure 4

C-type natriuretic peptide (CNP) overexpression lessens cartilage damage in K/BxN T cell receptor (TCR) mice. A and B, Photomicrographs of hematoxylin and eosin (H&E)–stained sagittal sections of the femorotibial joint of a 13-week-old male nontransgenic mouse (BxN), an arthritic mouse (K/BxN), a CNP-overexpressing mouse (Col2a1-NPPC–transgenic), and an arthritic and CNP-overexpressing mouse (K/BxN TCR,Col2a1-NPPC–transgenic). Femoral articular cartilage is shown (arrows). The images shown are from mice that had the median score for histologic severity within each genotypic group. Original magnification × 10 in A; × 40 in B. C, Photomicrographs of Safranin O–stained coronal sections of the femorotibial joints of 12-week-old female mice. The cartilage surface of the tibia plateau is shown (arrows). Bars = 100 μm. D, Photomicrographs of H&E-stained sagittal sections of the femorotibial joint of 12-week-old female mice. Although K/BxN TCR,Col2a1-NPPC–transgenic mice have pannus and synovial inflammation (solid arrows), there is less damage to the articular cartilage surface (dashed arrows). Bars = 100 μm.