Table 3: Treatment of LCH with CNS involvement

Dexamethasone, 2-CdA, retinoic acid, intravenous immunoglobulin (IV Ig), and cytarabine with or without vincristine have been used.

Retinoic acid was given at a dose of 45 mg/m2 daily for 6 weeks, then 2 weeks per month for 1 year.

IV g (400 mg/m2) was given monthly and chemotherapy consisting of oral prednisolone with or without oral or intravenous methotrexate and oral 6-mercaptopurine were given for at least 1 year.

Cytarabine 100 mg/m2 daily on days 1 to 5 during induction and 150 mg/m2 on day 1 of each maintenance cycle (every 2 weeks for 6 months).8