Figure 4.

Acetylcholine- (1 μmol/L) mediated relaxation (a), percentage attenuation of acetylcholine-mediated relaxation by L-NAME (b), and sodium nitroprusside- (SNP, 10 μmol/L, (c)) mediated relaxation determined in mesenteric resistance arteries isolated from WKY rats and SHRs submitted to low flow (LF), high flow (HF), or normal flow (NF) for 1, 3, 8, or 24 weeks. Values represent mean ± SEM (n = 12 rats per group). *P < 0.01, HF or LF versus NF arteries. ^# P < 0.05, SHRs versus WKY rats, within equivalent arteries (NF, LF, or HF).