Supplementary Table 4. The association between severity of gastroesophageal reflux disease (GERD) symptoms and self-reported heart disease and between severity of GERD symptoms and circulatory mortality by self-reported heart disease status.

Severity of symptoms	Association between self-reported heart disease and severity of reflux		Circulatory mortality	Among those without self-reported heart disease
			Among those with self-reported heart disease
	N	OR (95% CI)	N	HR (95% CI)	N	HR (95% CI)
Never	875	Referent	124	Referent	532	Referent
Mild	241	1.16 (1.00–1.35)	23	0.64 (0.41–1.01)	107	0.90 (0.73-1.11)
Moderate	1354	1.45 (1.33–1.59)	155	0.81 (0.64–1.03)	442	0.82 (0.72-0.93)
Severe	580	2.36 (2.10–2.64)	55	0.72 (0.52–0.99)	153	1.03 (0.86-1.24)
p for trend		<0.001		0.04		0.09

CI: Confidence interval; GERD: Gastroesophageal reflux disease; HR: Hazard ratio; N: Number of deaths; OR: Odds ratio.

ORs and HRs (95% CIs) are adjusted for the sociodemographic and lifestyle factors shown in Table 1. Odds ratios (95% CIs) for the association between self-reported heart disease and reflux severity was calculated using logistic regression models in which self-reported heart disease was the dependent variable.