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. Author manuscript; available in PMC: 2014 May 27.
Published in final edited form as: Chem Phys Lipids. 2013 Feb 26;169:46–56. doi: 10.1016/j.chemphyslip.2013.01.009

Fig. 2.

Fig. 2

The N-terminus of the S1P1 crystal structure (red) contains a helical segment that is packed across the TMH bundle (from TMH3 to TMH6) with the EC-1 and EC-2 loops packing against this N-terminal helix. This arrangement occludes ligand access to the receptor from the extracellular milieu (Hanson et al., 2012).