. Author manuscript; available in PMC: 2015 May 1.

Published in final edited form as: Mol Ecol. 2014 Apr 11;23(9):2242–2259. doi: 10.1111/mec.12733

Table 4.

Detoxification genes (AGAP last 5 digits) over-expressed in field-collected and colonized An. coluzzii larvae

Gene class	Field-collected 2^nd instar	Field-collected 4^th instar	CAM 4^th instar	Mali-NIH 4^th instar
CYP450	CYP301A1 (06082), CYP9J5 (12296)	CYP325C2 (02205), CYP325B1 (02210), CYP4D16 (13241)	CYP9K1 (00818), CYP6AA1 (02862), CYP6P3 (02865), CYP6P4 (02867). CYP6P1 (02868), CYP6S1 (08204), CYP6M1 (08209), CYP6M2 (08212), CYP6M4 (08214), CYP6Z3 (08217), CYP6Z2 (08218), CYP4H17 (08358), CYP4H27 (08552), CYP9J5 (12296)	CYP6M2 (08212), CYP4C36 (09241), CYP6M4 (08214), CYP12F1 (08022)
CE	COEBE4C (05370), COEBE2C (05371), COEBE3C (05372), COEAE3D (05758)	COEAE1D (05756)	COEAE1A (01723), COEAE3D (05758), COEJHE5E (05837), COE13O (11507)	---
GST	GSTD10 (04383), GSTE5 (09192), GSTE2 (09194), GSTE1 (09195), GSTE3 (09197)	GSTE2 (09194), GSTE1 (09195)	GSTT2 (00888), GSTD11 (04378), GSTD6 (04379), GSTD12 (04380), GSTD3 (04382)	GSTT2 (00888), GSTD11 (04378)
UGT	UGT5 (02783)	UGT5 (02783)	UGT (06222), UGT (07028), UGT (07029), UGT (11564)	---

CYP450, cytochrome P450; CE, carboxylesterase; GST, glutathione S transferase; UGT, UDP-glucuronosyltransferase. Genes underlined and bolded have been validated to metabolize insecticide (Daborn et al. 2012; David et al. 2013; Ranson et al. 2001); those in bold have been associated with insecticide resistance (David et al. 2013; Djouaka et al. 2008; Tene Fossog et al. 2013b)