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Ku80-deletion reduces intestinal tumors in APCMIN mice. A, Number of MIN tumors for APCMIN mice with +/+. +/− and −/− Ku80 genotypes. Number of mice observed in parentheses. B, Life spans for all cohorts of mice. Number of mice observed in parentheses. C, Balance between DNA mutations (MT) that exacerbate cancer and cell death or senescence (D-S) that ameliorate cancer.
