Fig. 3.

DME demethylates small, AT-rich euchromatic TEs. (A) Box plots showing absolute fractional demethylation of 50-bp windows within transposons. Each box encloses the middle 50% of the distribution, with the horizontal line marking the median, and vertical lines marking the minimum and maximum values that fall within 1.5 times the height of the box. Differences between size categories are significant (P < 0.001, Kolmogorov-Smirnov test). (B) Significant (P < 0.001, Kolmogorov-Smirnov test) Spearman correlation coefficients between extent of demethylation and chromatin features. (C) Distribution of TEs and significantly differentially methylated cyto-sines (DMCs) (CG context; P < 0.0001, Fisher's exact test) with respect to genes.