A: Identified epidemiological regions based on hierarchical clustering, using the Euclidian distance between weekly standardized HFMD time series. Provinces are color-coded by climatic region (black: cold-temperate, blue: mid-temperate, green: warm temperate, orange: subtropical, red: tropical). B: Map of the three epidemiological regions identified in panel A. C: Climate predictors of the two main clusters identified in panel A, based on stepwise discriminant analysis.