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. Author manuscript; available in PMC: 2014 May 27.
Published in final edited form as: Bone. 2007 Oct 17;42(2):332–340. doi: 10.1016/j.bone.2007.10.004

Fig. 5.

Fig. 5

Regulation of post-surgical synostosis in the engineered cranial suture. a. Microcomputed tomography (μCT) showing substantial progression of re-synostosis characterized as newly formed bone and mineralization (white arrows) in the resected cranial suture osteotomy site implanted with a placebo PLGA carrier after 4 weeks (c: coronal suture; s: sagittal suture). b. Secondary synostosis was substantially curbed upon the implantation of autologous MSCs and control-released TGFβ3 in a collagen carrier after 4 weeks. c. Quantification of new bone volume over total tissue volume (BV/TV) by computerized histomorphometric analysis showing significantly more mineralization in osteotomized synostosis suture healed with autologous MSCs and placebo collagen carriers than autologous MSCs and control-released TGFβ3 collagen carriers (P<0.05).