Fig. 5.
The phosphorylated form of p65 does not accumulate in the nucleus of Ado+Hcy-treated cells. Cells were pre-treated for 2 hours with medium alone (DMEM) or 500 µM adenosine and homocysteine (A+H), then stimulated with 10 ng/ml TNF for the indicated times. Cytosolic and nuclear fractions were prepared, and equal amounts of total protein (15 µg) were analyzed by western blotting.