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. 2014 Apr 30;15(1):323. doi: 10.1186/1471-2164-15-323

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© Komaki et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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A representative example of PKS-I gene cluster (#46 in Figure 2 ) (A), and its putative product (B). The cluster is specific to N. asteroides NBRC 15531^T. A. Domain organization. LM, loading module; m1 – m11, modules; KS, ketosynthase; AT, acyltransferase; ACP, acyl carrier protein; DH, dehydratase; KR, ketoreductase; ER, enoyl-reductase domains. Gray ’DH” domains are probably inactive. B. Chemical structure of intermediate polyketide chain predicted from the gene cluster #46 based on assembly line rule [46, 49].