Table 4.
The brief table of 10 most significant KEGG pathways (A) and GOBPs (B) for the 6 miRNA targets in separative analysis
| Pathways | Targeted by different miRNAs | rno-miR-129 | rno-miR-130a | rno-miR-130b | rno-miR-141 | rno-miR-218b | rno-miR-3588 |
|---|---|---|---|---|---|---|---|
| A | |||||||
| rno04070 Phosphatidylinositol signaling system | 4 | 1 | 1 | 1 | 0 | 1 | 0 |
| rno05212 Pancreatic cancer | 3 | 1 | 1 | 1 | 0 | 0 | 0 |
| rno04971 Gastric acid secretion | 3 | 1 | 1 | 1 | 0 | 0 | 0 |
| rno04010 MAPK signaling pathway | 3 | 1 | 1 | 1 | 0 | 0 | 0 |
| rno04622 RIG-I-like receptor signaling pathway | 3 | 1 | 1 | 1 | 0 | 0 | 0 |
| rno00380 Tryptophan metabolism | 3 | 1 | 1 | 1 | 0 | 0 | 0 |
| rno04730 Long-term depression | 3 | 1 | 1 | 1 | 0 | 0 | 0 |
| rno00410 beta-Alanine metabolism | 3 | 1 | 1 | 1 | 0 | 0 | 0 |
| rno04110 Cell cycle | 3 | 1 | 1 | 1 | 0 | 0 | 0 |
| rno04114 Oocyte meiosis | 3 | 1 | 1 | 1 | 0 | 0 | 0 |
| … | |||||||
| rno05410 Hypertrophic cardiomyopathy (HCM) | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Total pathways targeted by each miRNA | 47 | 48 | 47 | 0 | 1 | 0 | |
| B | |||||||
| GO:0016043 ~ cellular component organization and biogenesis | 5 | 1 | 1 | 1 | 1 | 0 | 1 |
| GO:0050789 ~ regulation of biological process | 5 | 1 | 1 | 1 | 1 | 0 | 1 |
| GO:0008283 ~ cell proliferation | 5 | 1 | 1 | 1 | 1 | 0 | 1 |
| GO:0065007 ~ biological regulation | 5 | 1 | 1 | 1 | 1 | 0 | 1 |
| GO:0048519 ~ negative regulation of biological process | 5 | 1 | 1 | 1 | 1 | 0 | 1 |
| GO:0006796 ~ phosphate metabolic process | 4 | 1 | 1 | 1 | 0 | 0 | 1 |
| GO:0030154 ~ cell differentiation | 4 | 1 | 1 | 1 | 0 | 0 | 1 |
| GO:0008104 ~ protein localization | 4 | 1 | 1 | 1 | 0 | 0 | 1 |
| GO:0051336 ~ regulation of hydrolase activity | 4 | 1 | 1 | 1 | 0 | 0 | 1 |
| GO:0051179 ~ localization | 4 | 1 | 1 | 1 | 0 | 0 | 1 |
| … | |||||||
| GO:0043434 ~ response to peptide hormone stimulus | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Different pathways predicted by each miRNA | 162 | 157 | 156 | 5 | 0 | 27 | |