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. 2014 May 8;15(1):350. doi: 10.1186/1471-2164-15-350

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© Behnke et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Clustering of significantly regulated life cycle gene groups. (A) Heatmap of life cycle regulated genes. A total of 5,969 genes were found to have significant expression differences (ANOVA .05). (B) Heatmap of cell growth related genes. Many genes with growth and/or metabolism related Gene Ontology were upregulated at the merozoite stage. (C) Heatmap of Apicomplexa specific genes. The ROP, GRA and MIC gene families were downregulated as a class and many SRS genes were upregualted upon entering the enteric stages.