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. 2014 May 10;15(1):354. doi: 10.1186/1471-2164-15-354

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© Farrell et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Lineage overview of the parasite strains used in this study. All are of the Type I genotype, with GT1 the sequenced reference genome available on ToxoDB.org [48]. The GT1 and RH strains are most likely descendants from the same clone [49]. All sequenced strains and mutants are outlined by red boxes; all are derived from the RH strain. Drug selections to generate transgenic lines are given between brackets in the lower box of each line. Mutagen dosage is expressed as the percentages of parasites being killed by mutagen treatment (measured by plaque assays). Phle: phleomycin; D-HR: double homologous recombination; 6-TX: 6-thioxanthine; Chl: chloramphenicol; FUDR: 5-fluoro-2'-deoxyuridine; HXGPRT: hypoxanthine-xanthine-guanine-phosphoribosyl transferase.