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. 2014 May 10;15(1):354. doi: 10.1186/1471-2164-15-354

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© Farrell et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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EMS generated mutants. (A) The incidence of various SNVs in protein coding regions versus those outside annotated open reading frames. Syn.: synonymous; non-syn: non-synonymous. The number between brackets is the percentage of mutations in each category. (B) The incidence of SNVs across the EMS mutants screened for resistance to pharmacologically induced egress using DTT (E2D2 and E4D5) or invasion enhancing compound 2 (E3E2) [42, 43]. These three mutants were generated using an EMS dosage inducing 70% killing. (C) The incidence of SNVs across the EMS mutants screened for resistance against 20 μM FUDR [15]. EMS7.5 and EMS10 were generated using 7.5 and 10 mM EMS, inducing 80% and 90% killing, respectively.