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. 2014 May 10;15(1):354. doi: 10.1186/1471-2164-15-354

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© Farrell et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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FUDR resistant mutants. (A) The resistance of Toxoplasma strains to varying concentrations of FUDR. Survival was determined by plaque formation relative to an untreated control. Error bars represent SD from 6 independent experiments. Both strains were initially selected for survival in the presence of 20 μM FUDR. (B) Proposed etiological mutation in UPRT identified in mutant EMS7.5. Genbank accession numbers for HsUPRT and DmUPRT are NP_659489 and CG5537, respectively.