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. 2014 May 10;2:54. doi: 10.1186/2051-5960-2-54

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© Groh et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Funduscopy of 16-month-old Cln3 ^+/+ and Cln3 ^-/- mice. A: IR fundus images revealed no obvious differences in general retinal appearance of Cln3 ^-/- mice compared with controls (n = 4 per group). However, based on the different genetic background, both Cln3 genotype groups showed brighter overall appearance of retinae in comparison with Ppt1 genotype groups (see Figure 2A). Optic disc and major blood vessels were well recognizable. B: Accumulation of hyperfluorescent profiles in the inner retinal layers of Cln3 ^-/- mice in comparison with Cln3 ^+/+ mice was obvious in BAF fundus images. Scale bars correspond to 50 μm of subtended retina.