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. 2014 May 10;2:54. doi: 10.1186/2051-5960-2-54

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© Groh et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Assessment of retina thickness in OCT volume scans. A: Representative interpolated thickness maps from retinal volume scans of 7-month-old Ppt1 ^+/+ and Ppt1 ^-/- mice and 16-month-old Cln3 ^+/+ and Cln3 ^-/- mice. A segmented circular OCT grid was centered on the optic disc and retina thickness was calculated by averaging the values of the 4 outer areas (yellow filling). Scale bars correspond to 70 μm of subtended retina. B: Retina thickness was significantly reduced in Ppt1 ^-/- and Cln3 ^-/- mice compared to age-matched control littermates (n = 4 per group). Student’s t-test. * P < 0.05.