Table 2.
Acute coronary syndrome, MI, and acute chest pain
| Reference | Inclusion/exclusion | Intervention/Subgroup | n | Mean age, years | Gender (% male) | Time point | PL | AS | AF | TS | DP | EQ-5D |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Arnold et al51 | (I) Myocardial ischemia at rest for ≥10 minutes presenting within the previous 48 hours, and elevated biomarkers of myocardial necrosis, ST depression of at least 0.1 mV, diabetes mellitus or a TIMI risk score of ≥3. (E) Persistent ST segment elevation, successful revascularization before randomization, and ECG abnormalities that interfere with interpretation of ischemia. |
1. Prior history of angina | 3,565 | 66.0 (median) | 62.6 | |||||||
| A. Ranolazine | Baseline | 54.5 (0.57) | 30.8 (0.70) | 52.1 (0.63) | 77.5 (0.43) | 37.7 (0.45) | 0.708 (0.70–0.72) | |||||
| B. Placebo | Baseline | 54.1 (0.57) | 30.6 (0.72) | 51.2 (0.65) | 77.5 (0.44) | 37.5 (0.47) | 0.706 (0.69–0.72) | |||||
| 2. No prior history of angina | 2,995 | 62.0 (median) | 68.0 | |||||||||
| A. Ranolazine | Baseline | 73.0 (0.65) | 39.2 (0.70) | 76.4 (0.64) | 85.9 (0.40) | 47.6 (0.54) | 0.793 (0.78–0.80) | |||||
| B. Placebo | Baseline | 73.5 (0.65) | 40.2 (0.74) | 76.7 (0.62) | 86.5 (0.41) | 48.4 (0.54) | 0.796 (0.79–0.81) | |||||
| Arnold et al52 | (I) ≥18 years, symptoms of myocardial ischemia at rest lasting at least 10 minutes and present within the previous 48 hours, and had at least one of: elevated biomarkers of myocardial necrosis, ST depression of ≥0.1 mV, diabetes mellitus or a TIMI risk score of ≥3. (E) Persistent ST segment elevation, revascularization before randomization, and ECG abnormalities that would interfere with interpretation of Holter monitoring for ischemia. |
Rose Dyspnea Scale: 0 | 972 | 59.5 | 75.3 | 1 month | 97.6 (0.31) | 54.7 (0.50) | 95.4 (0.40) | 92.5 (0.37) | 83.0 (0.54) | 0.942 (0.93–0.95) |
| Rose Dyspnea Scale: 1 | 318 | 59.7 | 67.3 | 1 month | 93.1 (0.84) | 56.9 (1.03) | 92.7 (0.82) | 90.0 (0.71) | 76.8 (1.11) | 0.914 (0.90–0.93) | ||
| Rose Dyspnea Scale: 2 | 205 | 60.9 | 61.5 | 1 month | 89.1 (1.36) | 55.6 (1.45) | 88.0 (1.32) | 90.8 (0.87) | 71.0 (1.57) | 0.889 (0.88–0.90) | ||
| Rose Dyspnea Scale: 3 | 170 | 60.7 | 57.6 | 1 month | 80.0 (1.85) | 57.9 (1.77) | 86.0 (1.53) | 86.9 (1.18) | 65.8 (2.06) | 0.855 (0.84–0.87) | ||
| Rose Dyspnea Scale: 4 | 170 | 60.6 | 64.1 | 1 month | 60.5 (2.35) | 56.1 (1.83) | 81.1 (1.90) | 85.7 (1.18) | 58.4 (2.23) | 0.795 (0.78–0.81) | ||
| Pettersen et al22 | (I) Discharge diagnosis of acute MI. | 408 | 65.5 | 71.0 | 2–3 years | 73.0 (1.23) | 68.0 (1.29) | 86.0 (1.10) | 81.0 (1.09) | 72.0 (1.15) | 0.851 (0.84–0.86) | |
| Asadi-Lari et al53 | (I) Admitted to acute cardiac unit with chest pain. | 242 | 69.7 | 59.0 | ||||||||
| 1. Women | Baseline | 49.3 (2.79) | 48.1 (1.92) | 73.9 (3.00) | 84.2 (2.11) | 57.7 (2.70) | 0.765 (0.75–0.79) | |||||
| 2. Men | Baseline | 55.1 (2.45) | 53.2 (1.61) | 75.6 (2.34) | 87.6 (1.46) | 63.1 (2.13) | 0.791 (0.77–0.81) |
Notes: SAQ values include standard error; EQ-5D values include 95% confidence intervals.
Abbreviations: I, inclusion criteria; E, exclusion criteria; TIMI, Thrombolysis in Myocardial Infarction; ECG, electrocardiogram; SAQ, Seattle Angina Questionnaire; PL, physical limitation; TS, treatment satisfaction; AF, angina frequency; AS, angina stability; DP, disease perception; EQ-5D, European Quality of Life-5 Dimensions.