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. Author manuscript; available in PMC: 2014 Jun 19.
Published in final edited form as: Nature. 2013 Nov 6;504(7480):427–431. doi: 10.1038/nature12715

Figure 3. Visual fixation between 2 and 6 months relative to diagnosis at year 3.

Figure 3

Individual curve fits for, a, eye fixation data, and, b, change-in-fixation data for typically-developing infants (blue) and infants later diagnosed with ASD (red). c, The extent of between-group overlap in distributions of change-in-fixation data. For internal validation, each infant was tested as a validation case in relation to the remainder of the data (leave-one-out cross-validation, LOOCV). Area plots in d and e show LOOCV mean and 95% prediction intervals for individual trajectories of d, eye fixation, and e, change-in-fixation data; f, shows extent of between-group overlap in change-in-fixation data (mean and 95% CI). g–i and j–l repeat the same analyses for body fixation. m, plots the joint distribution of change in eye and body fixation. n, 6 male infants, not part of the original sample, were tested as an external validation.