Table 3.
Pearson’s correlation coefficients between the rate constants k 1, k 2, k 3, MR FDG and v B and histological assessed tumor characteristics. Values from both breast cancer xenograft models were utilized, and the p-values (in parentheses) were obtained using two-sided t-tests
| k 1 (min−1) | k 2 (min−1) | k 3 (min−1) | MR FDG (min−1) | v B | |
|---|---|---|---|---|---|
| Necrotic fraction | −0.03 (p = 0.91) | 0.09 (p = 0.74) | 0.06 (p = 0.84) | 0.23 (p = 0.38) | −0.34 (p = 0.19) |
| Hypoxic fraction | −0.42 (p = 0.10) | −0.10 (p = 0.72) | 0.37 (p = 0.16) | 0.37 (p = 0.16) | −0.30 (p = 0.26) |
| Microvessel density | 0.43 (p = 0.07) | 0.22 (p = 0.37) | −0.29 (p = 0.23) | −0.48 (p = 0.04) | 0.61 (p = 0.01) |
| Relative level of (HK2) | −0.33 (p = 0.32) | 0.08 (p = 0.82) | 0.776 (p = 0.01) | 0.788 (p < 0.01) | −0.804 (p < 0.01) |
| Ki-67 score | −0.58 (p = 0.01) | −0.20 (p = 0.43) | 0.62 (p = 0.01) | 0.72 (p < 0.01) | −0.43 (p = 0.09) |
| GLUT1 score | 0.69 (p < 0.01) | 0.29 (p = 0.266) | −0.73 (p < 0.01) | −0.76 (p < 0.001) | 0.42 (p = 0.10) |