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. Author manuscript; available in PMC: 2014 Dec 17.
Published in final edited form as: Sci Signal. 2013 Dec 17;6(306):ra108. doi: 10.1126/scisignal.2004405

Fig. 7.

Fig. 7

S1P attenuates mitochondrial translocation of cofilin 2 and Bax by ischemia/reperfusion injury in the isolated heart. Isolated mouse hearts were perfused with Veh or S1P prior to 20 min ischemia followed by 30 min reperfusion. (A) Representative blots showing mitochondrial cofilin 2 and Bax abundance. (B) Quantification of mitochondrial cofilin 2 and (C) mitochondrial Bax. n = 4–6 animals per group. (D) Hypothetical schema showing the role of the S1P-RhoA-PKD1-SSH1L signaling pathway in oxidative stress induced cofilin 2 and Bax translocation to mitochondria and cardiomyocyte cell death.