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. 2014 May 27;9(5):e97153. doi: 10.1371/journal.pone.0097153

Figure 4. Representative structures of the ensemble of the sm27/FGF2 complex that recapitulates calculated and experimental data.

Figure 4

From structural representations of two different orientations of the sm27-FGF2 complex (a and c) it is immediately evident that the ligand can occupy a diverse range of conformations/configurations and the protein dynamically adapts to them. Sm27 molecule is shown in magenta sticks, while protein side-chains involved in interaction (Y33, K35, N36, R53, K128, R129, K134, Q143, K144, A145) are shown as blue lines. In b and d the same views of sm27-FGF2 complex are offered and the position of heparin (yellow sticks) and FGFR1 (dark olive and orange cartoons), deduced from X-ray structure (PDB ID: 1FQ9), are shown.