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. 2014 May 27;12(5):e1001872. doi: 10.1371/journal.pbio.1001872

Phylogenetic distances and metabolome evolution. Not all tissues follow the molecular clock: while kidney and visual cortex (V1) accumulated metabolic changes proportionally to species' divergence time (MY = million years), metabolomes of skeletal muscle and the brain's prefrontal cortex (PFC) evolved exceptionally rapidly in the human lineage.

Phylogenetic distances and metabolome evolution. Not all tissues follow the molecular clock: while kidney and visual cortex (V1) accumulated metabolic changes proportionally to species' divergence time (MY = million years), metabolomes of skeletal muscle and the brain's prefrontal cortex (PFC) evolved exceptionally rapidly in the human lineage.