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. 2014 May 27;12(5):e1001869. doi: 10.1371/journal.pbio.1001869

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© 2014 Fortelny et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The structure of the core of the human protease web is comprised of 255 connected proteases and inhibitors that form the largest connected component. Proteins are designated by their UniProt gene names. Proteases are circles and inhibitors are diamonds. Nodes are color-shaded according to their betweenness. All nodes are positioned from top to bottom by decreasing reachability, which is indicated by the depth of shade of the green background. Edges are cleavages (with arrow head) or inhibitions (“T” head). Nodes of known protease cascades are labeled and marked by dashed circles. The figure is rendered in high resolution for click to zoom.