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. 2014 May 27;12(5):e1001869. doi: 10.1371/journal.pbio.1001869

Figure 7. Proteases and their inhibitors involved in multiple, discreet biological processes.

Figure 7

(A) A matrix showing the annotation of proteases and inhibitors with selected, protease-specific biological processes based on Gene Ontology [61]. Proteins annotated with more than one term are displayed. (B) A subnetwork of the protease web connecting TIMP1 to coagulation: TIMP1 (UniProt: P01033) inhibits MMP10 (UniProt: P09238) and MMP1 (UniProt: P03956), which both cleave and activate MMP9 (UniProt: P14780), which cleaves PLG (UniProt: P00747). Similarly, MMP1 and MMP9 cleave and inactivate serpin A1 (UniProt: P01009), which is an inhibitor of PLG.