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. 2014 May 27;12(5):e1001869. doi: 10.1371/journal.pbio.1001869

Table 1. Human and mouse proteolytic networks created from all annotated proteases, inhibitors, and substrates.

Organism Total Nodes Largest Connected Component Proteases with Substratesa Inhibitors with Target Proteasesa Edges
Human 1,230 1,183 244 41 4,905
Mouse 1,393 1,377 88 47 3,852
a

Protease and inhibitor numbers refer to those with at least one annotated cleavage or inhibition, respectively, in MEROPS and TopFIND.