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. 2014 May 27;9(5):e98295. doi: 10.1371/journal.pone.0098295

Figure 5. CBX7 modulates the activity of the CBX7-regulate gene promoters.

Figure 5

HEK 293 cells were transiently co-transfected with increasing amounts of CBX7 expression vector and a constant amount of vector containing the luciferase gene under the control of the promoters of CBX7-regulated genes. Increasing amounts of CBX7 enforced the expression of the reporter gene under the control of the FOS, FOSB and EGR1 promoter regions (A), whereas repressed the activity of the reporter gene under the control of the SPP1, SPINK1 and STEAP1 promoters (B).The relative activity of firefly luciferase expression was standardized to a transfection control, using β-galactosidase. The scale bars represent the mean ± SD (n = 3).