Table I.
Final diagnoses in 703 patients with PALF
| Final diagnosis | Number of patients (%) (n = 703) | Number of patients younger than 7 months (%) (n = 149) | Number of patients at least 7 months (%) (n = 554) |
|---|---|---|---|
| Indeterminant | 329 (46.8%) | 61 (40.9%) | 268 (48.4%) |
| Drug toxicity | 111 (15.8%) | 3 (2.0%) | 108 (19.5%) |
| Acetaminophen overdose | 88 (12.5%) | 2 (1.3%) | 86 (15.5%) |
| Other drugs | 23 (3.3%) | 1 (0.7%) | 22 (4.0%) |
| Autoimmune hepatitis | 48 (6.8%) | 0 (0.0%) | 48 (8.7%) |
| Metabolic disease | 68 (9.7%) | 27 (18.1%) | 41 (7.4%) |
| Fatty acid oxidation defect | 2 (0.3%) | 0 (0.0%) | 2 (0.4%) |
| Tyrosinemia | 8 (1.1%) | 5 (3.4%) | 3 (0.5%) |
| Wilson disease | 23 (3.3%) | 0 (0.0%) | 23 (4.2%) |
| Other | 35 (5.0%) | 22 (14.7%) | 13 (2.3%) |
| Infections | 45 (6.4%) | 20 (13.4%) | 25 (4.5%) |
| Hepatitis A | 5 (0.7%) | 0 (0.0%) | 5 (0.9%) |
| Hepatitis B | 2 (0.3%) | 0 (0.0%) | 2 (0.4%) |
| EBV | 8 (1.1%) | 0 (0.0%) | 8 (1.4%) |
| Other | 30 (4.3%) | 20 (13.4%) | 10 (1.8%) |
| Other diagnosis | 102 (14.5%) | 38 (25.5%) | 64 (11.6%) |