Table 2.
Correlation between telomerase activity expression and clinicopathological parameters for patients with colorectal cancer
| Variable | Normal mucosa | Cancer tissue | ||||
|---|---|---|---|---|---|---|
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| No. | Mean ± SD | p value | No. | Mean ± SD | p value | |
| Sex | 0.52 | 0.66 | ||||
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| Male | 28 | 0.0126 ± 0.0037 | 28 | 0.0055 ± 0.0014 | ||
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| Female | 21 | 0.0105 ± 0.0029 | 21 | 0.0070 ± 0.0019 | ||
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| Smoke | 0.88 | 0.72 | ||||
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| Yes | 19 | 0.0118 ± 0.0026 | 19 | 0.0066 ± 0.0017 | ||
|
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| No | 30 | 0.0126 ± 0.0060 | 30 | 0.0055 ± 0.0019 | ||
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| BMI | 0.09 | 0.34 | ||||
|
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| < 25 | 22 | 0.0073 ± 0.0012 | 22 | 0.0052 ± 0.0011 | ||
|
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| ≥ 25 | 27 | 0.0151 ± 0.0040 | 27 | 0.0075 ± 0.0021 | ||
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| Dukes stage | 0.57 | 0.011 | ||||
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| A | 0 | — | 0 | — | ||
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| B | 25 | 0.0140 ± 0.0039 | 25 | 0.0104 ± 0.023 | ||
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| C | 19 | 0.0095 ± 0.0035 | 19 | 0.0040 ± 0.0012 | ||
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| D | 5 | 0.0098 ± 0.0010 | 5 | 0.0024 ± 0.0008 | ||
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| A+B | 25 | 0.0140 ± 0.0039 | 0.34 | 25 | 0.0103 ± 0.0024 | 0.005 |
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| C+D | 24 | 0.00096 ± 0.0028 | 24 | 0.0037 ± 0.0044 | ||
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| TNM stage | ||||||
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| I | 6 | 0.0027 ± 0.0009 | 6 | 0.0047 ± 0.0016 | ||
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| II | 19 | 0.0114 ± 0.0021 | 19 | 0.0155 ± 0.0035 | ||
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| III | 18 | 0.0040 ± 0.0012 | 18 | 0.0106 ± 0.0035 | ||
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| IV | 6 | 0.0034 ± 0.0010 | 6 | 0.0081 ± 0.0017 | ||
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| I–II | 25 | 0.0097 ± 0.0018 | 0.029 | 25 | 0.0133 ± 0.0028 | 0.18 |
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| III–IV | 24 | 0.0038 ± 0.0009 | 24 | 0.0099 ± 0.0026 | ||
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| Grade | 0.89 | 0.21 | ||||
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| Low | 4 | 0.0096 ± 0.0039 | 4 | 0.0123 ± 0.0045 | ||
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| Moderate | 41 | 0.0120 ± 0.0028 | 41 | 0.0057 ± 0.0013 | ||
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| High | 4 | 0.0088 ± 0.0018 | 4 | 0.0045 ± 0.0024 | ||
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| Tumour site | 0.09 | 0.20 | ||||
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| Right | 8 | 0.0209 ± 0.089 | 8 | 0.0101 ± 0.0036 | ||
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| Left | 7 | 0.0092 ± 0.0015 | 7 | 0.0081 ± 0.0032 | ||
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| Sigmoid | 16 | 0.0133 ± 0.0040 | 16 | 0.0054 ± 0.0016 | ||
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| Rectum | 18 | 0.0053 ± 0.0012 | 18 | 0.0034 ± 0.0012 | ||
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| Total* | 49 | 0.0114 ± 0.0023 | 49 | 0.0064 ± 0.0012 | ||
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| Right colon | 15 | 0.0151 ± 0.0046 | 0.09 | 15 | 0.0092 ± 0.0024 | 0.043 |
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| Left colon | 34 | 0.0089 ± 0.0092 | 34 | 0.0043 ± 0.0010 | ||
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| Colon | 31 | 0.0144 ± 0.0032 | 0.012 | 31 | 0.0078 ± 0.0016 | 0.035 |
|
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| Rectum | 18 | 0.0053 ± 0.0012 | 18 | 0.0034 ± 0.0012 | ||
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| Right colon | 8 | 0.0209 ± 0.0089 | 0.047 | 8 | 0.0101 ± 0.0036 | 0.13 |
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| Left colon | 23 | 0.0115 ± 0.0023 | 23 | 0.0066 ± 0.0016 | ||
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| Rectum | 18 | 0.0053 ± 0.0012 | 18 | 0.0033 ± 0.0012 | ||
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| Ki-67 expression | 0.022 | 0.66 | ||||
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| Negative | 3 | 0.0033 ± 0.0018 | — | 0.0050 ± 0.0025 | ||
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| Positive | 46 | 0.0119 ± 0.0024 | — | 0.0065 ± 0.0013 | ||
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| p53 expression | 0.12 | 0.037 | ||||
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| Negative | 16 | 0.0173 ± 0.0058 | — | 0.0103 ± 0.0033 | ||
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| Positive | 33 | 0.0093 ± 0.0022 | — | 0.0048 ± 0.0010 | ||
BMI = body mass index; SD = standard deviation; TNM = tumour-node-metastasis.
*
p = 0.006 for cancer versus normal p value.