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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Curr Opin Genet Dev. 2014 Feb 15;0:68–73. doi: 10.1016/j.gde.2013.11.019

Figure 3. Remodeling of roX2 acts a structural switch to provide a platform for Msl2 recruitment and subsequent DCC assembly.

Figure 3

(A) The helicase Mle is recruited to the roX2 ncRNA.

(B) Mle helicase activity remodels roX2 conformation in an ATP-dependent manner.

(C) Remodeled roX2 serves as a platform for Msl2 recruitment.

(D) Recruitment of Msl2 triggers DCC assembly and spreading across the X chromosome.