Table 3.
Serum steroid concentrations associated with Catecholamine-Resistant Hypotension
| Hypotension | |||||
|---|---|---|---|---|---|
| None, minimal, mild, or moderate (n=81) | Catecholamine-resistant (n=14) | ||||
| median (ng/ml) | interquartile range (ng/ml) | median (ng/ml) | interquartile range (ng/ml) | p-value* | |
| Cortisol-pre | 11.4 | 7.8–31 | 12.3 | 6.9–33 | - |
| Cortisol-ACTH | 87.7 | 62–137 | 80.1 | 43–178 | - |
| Cortisol-postop | 29.2 | 11–54 | 8.9 | 5.1–12 | 0.007 |
| 17OHP-pre | 1.6 | 0.6–4.2 | 2.4 | 2.0–3.1 | 0.072 |
| 17OHP-ACTH | 2.6 | 1.1–5.7 | 3.8 | 2.7–6.1 | - |
| 17OHP-postop | 1.0 | 0.5–3.0 | 1.1 | 0.7–1.6 | - |
| Cortisone-pre | 16 | 12–24 | 15 | 10–20 | - |
| Cortisone-ACTH | 17 | 14–24 | 16 | 10–21 | - |
| Cortisone-postop | 16 | 13–26 | 12 | 7.0–20 | 0.035 |
| 11-deoxycortisol-pre | 2.5 | 1.4–4.0 | 1.3 | 1.3–4.1 | - |
| 11-deoxycortisol-ACTH | 5.4 | 3.1–8.3 | 4.2 | 3.1–9.1 | - |
| 11-deoxycortisol-postop | 2.5 | 1.4–4.4 | 1.1 | 0.7–2.0 | 0.009 |
| 21-deoxycortisol-pre | 2.1 | 1.0–4.0 | 1.3 | 1.1–4.1 | - |
| 21-deoxycortisol-ACTH | 5.4 | 3.1–8.3 | 4.2 | 3.1–9.2 | - |
| 21-deoxycortisol-postop | 2.5 | 1.1–4.3 | 1.1 | 0.3–2.0 | 0.027 |
| Progesterone-pre | 0.5 | 0.2–1.0 | 0.5 | 0.5–0.7 | - |
| Progesterone -ACTH | 0.8 | 0.3–1.5 | 0.8 | 0.7–1.6 | - |
| Progesterone-postop | 0.4 | 0.1–0.9 | 0.3 | 0.1–0.9 | - |
| 11-DOC-pre | 0.09 | 0.0–0.3 | 0.15 | 0.0–0.8 | - |
| 11-DOC-ACTH | 0.42 | 0.2–0.8 | 0.45 | 0.1–2.5 | - |
| 11-DOC-postop | 0.13 | 0.0–0.6 | 0.02 | 0.0–0.6 | - |
| Corticosterone-pre | 1.4 | 0.6–3.1 | 0.9 | 0.4–5.9 | - |
| Corticosterone-ACTH | 16.1 | 8.6–29 | 9.6 | 6.2–31 | - |
| Corticosterone-postop | 1.7 | 0.8–5.6 | 0.9 | 0.4–1.5 | 0.057 |
| Androstenedione-pre | 0.5 | 0.2–0.8 | 0.4 | 0.3–0.6 | - |
| Androstenedione-ACTH | 1.0 | 0.4–1.5 | 0.9 | 0.3–1.7 | - |
| Androstenedione-postop | 0.3 | 0.1–0.6 | 0.2 | 0.1–0.3 | 0.045 |
| DHEAS-pre | 963 | 525–2141 | 2317 | 819–4073 | - |
| DHEAS-ACTH | 1639 | 847–3044 | 2131 | 469–4102 | - |
| DHEAS-postop | 751 | 283–1793 | 535 | 370–1533 | - |
*
Mann-Whitney test was used to compare the variables. p-values ≥0.1 are not shown.
Definitions: pre, values obtained prior to ACTH stimulation test (prior to ligation); ACTH, values obtained 60 min after ACTH stimulation (prior to ligation); postop, values obtained between 10–12 hr after ligation.