Effect of Ept7 on body weight in male rats. Rats were treated as described in Fig. 3. Body weight was evaluated at 9 weeks of age, the time treatment was initiated (a), and 21 weeks of age, the time the animals were euthanized (b). Each data bar represents the mean ± standard error of the mean; n = 9–10 rats per group in a, 5–6 rats per group in b. 1, p ≤ 0.05 for comparison between sham treated and DES treated rats of same strain. 2, p ≤ 0.05 for comparison to ACI rats that received the same treatment. 3, p ≤ 0.05 for comparison to BN rats that received the same treatment