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. Author manuscript; available in PMC: 2014 May 27.
Published in final edited form as: Semin Cell Dev Biol. 2014 Jan 3;0:74–85. doi: 10.1016/j.semcdb.2013.12.014

Fig. 1.

Fig. 1

p53 tumor-derived mutants examined in knock-in mouse models. The p53 tumor-derived mutants studied in mouse models and described in this review. Wild-type p53 is shown for reference. p53 functional domains: TAD1 = transactivation domain 1; TAD2 = transactivation domain 2; PRD = proline rich domain; DBD = DNA-binding domain; OD = oligomerization domain; CTD = C-terminal domain. Triangles denote mutated amino acid. Stippling indicates regions of p53 replaced with human sequences in the HUPKI mouse models.