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. Author manuscript; available in PMC: 2015 Feb 10.
Published in final edited form as: Chembiochem. 2014 Jan 13;15(3):413–424. doi: 10.1002/cbic.201300577

Table 2.

Residues critical to ACh binding and their corresponding homologous residues in the α3 and β2 subunits of the heteropentameric nAChR homology model.

Primary Subunit Reference Structure α Subunit of Tm-nAChR α3 Subunit β2 Subunit
A-loop Y93 Y93 Y95
B-loop W149 W149 W151
C-loop Y190-C192-C193-Y198 Y190-C192-C193-Y197 P191-D192-D193-Y196
Complimentary Subunit Reference structure δ Subunit of Tm-nAChR α3 Subunit β2 Subunit
D-loop E189 E175 E177
E-loop T119 T117 F119
F-loop W57 W55 W57