Table 2.

Standard MRI protocol for the diagnosis of CAA

Sequence	Expected role for the diagnosis
Minimum required protocol
T2*-weighted image	Depiction of haemosiderin depositions suggestive of chronic ICHs, MBs and SS
Fluid-attenuated inversion recovery image	Depiction of acute and subacute SAHs, and white matter signal changes
Diffusion-weighted image	Depiction of acute microinfarction Evaluation of vasogenic oedema due to CAA-related inflammation
Optional sequence for the diagnosis of CAA
Susceptibility-weighted image	Depiction of haemosiderin depositions, clearer than T2*-weighted image
Additional sequences for differential diagnosis
T1-weighted image	Depiction of T1 shortening due to methaemoglobin and melanin
Contrast-enhanced T1-weighted image	Differentiation between haemorrhagic tumours and other lesions
Magnetic resonance angiogram	Evaluation of vascular disorders such as vasculitis

CAA cerebral amyloid angiopathy, ICH intracerebral haemorrhage, MB microbleed, MRI magnetic resonance imaging, SAH subarachnoid haemorrhage, SS superficial siderosis