. 2014 Feb 12;5(3):375–385. doi: 10.1007/s13244-014-0312-x

Table 3.

Classic and modified Boston criteria [11, 19]

	Classic Boston criteria	Modified Boston criteria
Definite CAA	Full post-mortem examination demonstrating:	No modification
	- Lobar, cortical or corticosubcortical haemorrhage
	- Severe CAA with vasculopathy
	- Absence of other diagnostic lesion
Probable CAA with supporting pathology	Clinical data and pathological tissue (evaluated) haematoma or cortical biopsy) demonstrating:	No modification
	- Lobar, cortical or corticosubcortical haemorrhage
	- Some degree of CAA in specimen
	- Absence of other diagnostic lesion
Probable CAA	Clinical data and MRI or CT demonstrating:	Clinical data and MRI or CT demonstrating:
	- Multiple haemorrhages restricted to lobar, cortical or corticosubcortical regions (cerebellar haemorrhage allowed)	- Multiple haemorrhages restricted to lobar, cortical or corticosubcortical regions (cerebellar haemorrhage allowed), or
	- Age ≥55	- Single lobar, cortical, or corticosubcortical haemorrhage and focal or disseminated superficial siderosis
	- Absence of other cause of haemorrhage	- Age ≥55
	- Absence of other cause of haemorrhage	- Absence of other cause of haemorrhage or superficial siderosis
Possible CAA	Clinical data and MRI or CT demonstrating:	Clinical data and MRI or CT demonstrating:
	- Single lobar, cortical or corticosubcortical haemorrhage	- Single lobar, cortical or corticosubcortical haemorrhage, or
	- Age ≥55	- Focal or disseminated superficial siderosis
	- Absence of other cause of haemorrhage	- Age ≥55
	- Absence of other cause of haemorrhage	- Absence of other cause of haemorrhage or superficial siderosis