Figure 3.

Treatment with CDPPB during extinction training attenuates cue-induced reinstatement of ethanol-seeking behavior. Rats from this experiment were trained to self-administer ethanol using the sucrose-fading paradigm (average ethanol consumption in a 30 min session was 0.95 g/kg). On the day after the final day of extinction, rats were exposed to a session of cue-induced reinstatement of ethanol-seeking behavior by placing them in the operant chamber and exposing them to the ethanol cue. A, Whereas the number of extinction sessions were truncated due to the absence of ethanol cues during extinction training, CDPPB significantly reduced active lever responding on multiple days. *p < 0.02. B, Extinction training resulted in a significant reduction in active lever responding in both groups compared with self-administration levels. *p < 0.001. Rats that displayed CDPPB-facilitated extinction learning exhibited significant attenuation of cue-induced reinstatement when exposed to ethanol-associated cues. #p = 0.001; n = 6.