Figure 5.

CDPPB reversed extinction-induced enhancement of eNMDA currents in the PrL but not the IfL cortex. Rats were trained to self-administer ethanol using an ethanol pre-exposure paradigm and then administered vehicle or CDPPB during abstinence (ABST) or extinction training (EXT). A, CDPPB did not significantly alter the amplitude of eNMDA currents in the PrL cortex of ABST rats. However, EXT enhanced eNMDA currents in Vehicle treated animals (#, p = 0.033) and this increase was prevented by CDPPB treatment (*p = 0.037). B, Input-output curves for vehicle versus CDPPB from ABST rats were not significantly different. C, In contrast, the input-output curves for EXT where significantly different at higher stimulation intensity. Symbols indicate significant difference from respective controls. *p < 0.033; #p < 0.008. D, In the IfL cortex, there was a main effect of extinction training (indicated by an asterisk above the bar; p = 0.035), but this increase as not altered by CDPPB treatment. E, F, There were no significant differences in the input-output relationship of eNMDA currents between any of the drug treatment and training conditions in IfL cortex (n = 6 for all groups except EXT/CDPPB, for which n = 7).