Figure 9.

Local administration of MTEP into the PrL cortex during extinction training did not block the facilitating effects of CDPPB on extinction learning. Rats from this experiment were trained to self-administer ethanol using the ethanol pre-exposure technique (the average ethanol consumption for 30 min was 0.96 g/kg). A, Before extinction training, there were no differences between the two groups in ethanol self-administration (p > 0.05). B, Treatment with MTEP before each daily extinction session resulted in a significant main effect of session (p = 0.001; n = 6), but no treatment × session interaction (p > 0.05). C, Rats treated with MTEP before CDPPB administration did not differ from controls in the number of extinction sessions to reach extinction criteria (p > 0.05). D, Diagram of coronal rat brain sections showing the location of microinjector tips (dark circles) in the PrL cortex.