Figure 5.

Slowing diffusion alters α2-IPSCs, but not D2-IPSCs, unless reuptake is inhibited. A, Averaged α2-IPSC (n = 10) illustrating the effect of dextran (5% w/v). B, Averaged D2-IPSC (n = 9) illustrating the lack of effect of dextran. C, Averaged D2-IPSC in the presence of cocaine (500 nm; n = 6) illustrating the effect of dextran. D, E, Quantification of the amplitude (D) and decay time (E) of IPSCs recorded in control solution (colored bars) and dextran (gray bars; Student's paired t test). n.s., p > 0.05; *p < 0.05; ***p < 0.001; error bars indicate ± SEM.