Fig. 1.

Cell-extracellular matrix (ECM) and cell-cell interaction mediated by integrins and E-cadherin. Integrin-mediated focal adhesion kinase (FAK) phosphorylation results in activation of p190RhoGAP leading to a reduction in stress fibers (A) and activation of protein kinase B (PKB) leading to cell survival (B). Disassociation of p120 catenin from the E-cadherin-catenin complex (C) results in activation of Rac1 and Cdc42 as well as inhibition of RhoA activity. Engulfment of adjacent apoptotic cells (D) is induced by Rac1 activation mediated by integrin.