Table 1.
Infusion schedule
|
Time (min) |
Infusion rate |
Dose in 30 minutes |
Cumulative dose |
|
|---|---|---|---|---|
| (mg/h) | (mL/h) | (mg) | (mg) | |
|
Infusion 1 | ||||
| 0-30 |
50 |
12.5 |
25 |
25 |
| 31-60 |
100 |
25 |
50 |
75 |
| 61-90 |
150 |
37.5 |
75 |
150 |
| 91-120 |
200 |
50 |
100 |
250 |
| 121-150 |
250 |
62.5 |
125 |
375 |
| 151-180 |
300 |
75 |
150 |
525 |
| 181-210 |
350 |
87.5 |
175 |
700 |
| 211-240 |
400 |
100 |
200 |
900 |
| 241-255 |
400 |
100 |
200 |
1000 |
|
Infusion 2, 3 and 4 | ||||
| 0-30 |
250 |
62.5 |
125 |
125 |
| 31-60 |
600 |
150 |
300 |
425 |
| 61-90 |
600 |
150 |
300 |
725 |
| 91 ≈ 120 | 600 | 150 | 275 | 1000 |
The total estimated time to complete a 1000-mg dose at Infusion 1 is 4 hours, 15 minutes (4.25 hours) with 8 infusion rate changes. The total estimated time to complete a 1000-mg dose (1000 mg diluted in 250 mL of normal saline or D5W) at Infusion 2, 3 and 4 is approximately 2 hours with 1 infusion rate change.