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Molecular models of mitochondrial division and fusion. (a) Mitochondrial division involves communication between extra-mitochondrial division factors and internal mitochondrial structures. See text for details. (b) Mitochondrial fusion requires the sequential interaction of the MOM and MIM. MOM fusion is mediated by Mfn1/2, and MIM fusion is mediated by Opa1. Mfn2 is also localized to the ER and functions to tether the ER and mitochondria.
