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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: J Immunol. 2014 Apr 28;192(11):5305–5313. doi: 10.4049/jimmunol.1302983

Figure 7. Staurosporine inhibits the fMLF-induced cross-desensitization of CCR1-driven chemotactic activity of HR1R2F cells.

Figure 7

(A) The chemotaxis response of HR1R2F cells to CCL3 at the indicated agonist concentrations was determined. Cells were pretreated with (triangles) or without (circles) 1 μM fMLF for 5 min prior to analysis of the chemotactic response to CCL3. (B) HR1R2F cells were pretreated with staurosporine at the designated concentrations for 5 min prior to treatment with 1 μM fMLF for 5 min, and the chemotactic response of these cells to 5nM CCL3 was determined. The results are expressed as the chemotactic response where the cells which were not staurosporine or fMLF treated were set arbitrarily to 100%. *p<0.05 compared to the chemotaxis response in the absence of staurosporine.